Prediction of protein-protein interactions

1. Predicting whether two proteins interact or not given their amino acid sequences

Go to the PSOPIA site.

Reference
Murakami, Y. and Mizuguchi, K. (2014). “Homology-based prediction of interactions between proteins using Averaged One-Dependence Estimators”, BMC Bioinformatics, 15:213.


2. Predicting protein-binding sites given a single amino acid sequence

Go to the PSIVER site.

Reference
Murakami, Y. and Mizuguchi, K. (2010). “Applying the Naive Bayes classifier with kernel density estimation to the prediction of protein-protein interaciton sites”, Bioinformatics, 26 (15): 1841-1848.
doi:10.1093/bioinformatics/btq302


3. Predicting protein-binding sites given a pair of amino acid sequences

Go to the PPiPP site.

Reference
Ahmad, S. and Mizuguchi, K. (2011). “Partner-aware prediction of interacting residues in protein-protein complexes from sequence data”, PLoS One (2011) 6(12)e29104.

Mizuguchi, K. (2015). タンパク質間相互作用 “生命ネットワークの基本部品の構造を解明する”, The Biophysical Society of Japan. (This site is presented only in Japanese.)