Kenji Mizuguchi

BRIEF PERSONAL HISTORY

1995: PhD in Chemistry (unclassified), Department of Chemistry, Kyoto University
1995: Visiting Scholar (Fellow of theJapan Society for the Promotion of Science), Department of Crystallography, Birkbeck College, University of London
1996-2000: Long-Term Fellow of theHuman Frontier Science Programand Research Associate, Department of Biochemistry, University of Cambridge
2000-2006: TheWellcome TrustResearch Career Development Fellow (hosting an independent research laboratory), Department of Biochemistry, University of Cambridge
2004-2006: University Lecturer, Department of Applied Mathematics and Theoretical Physics (jointly held in Department of Biochemistry), University of Cambridge
2006-2015: Group Leader, National Institute of Biomedical Innovation
2007-: Guest professor, Graduate School of Frontier Biosciences, Osaka University
2015-: Group Leader, National Institutes of Biomedical Innovation, Health and Nutrition (new organizational name)
2015-: Guest professor, Graduate School of Pharmaceutical Sciences, Osaka University

RESEARCH INTERESTS

Bioinformatics and computational biology for drug discovery

Major achievements
Development of a highly successful method for protein structure prediction (FUGUE)

  • One of the best performing structure prediction methods at the CASP (Critical Assessment of Techniques for Protein Structure Prediction) and other international experiments
  • Among the most popular software programmes of its kind (cited >1000; JMB 2001)
  • Commercialized by Tripos Inc.

Data integration and database development

  • TargetMine, an integrated data warehouse for candidate gene prioritization and target discovery
  • Toxygates, interactive toxicity analysis on a hybrid microarray and linked data platform
  • HOMSTRAD, one of the first on-line databases for structure-based alignments

Successful (experimentally validated) predictions of protein structure, function and interaction

  • Examples include developmental regulators, metabolic enzymes in pathogenic microorganisms and proteins involved in cancer and psychiatric disorders
  • Identified potential novel targets for hepatitis C and other diseases using TargetMine
  • Predicted protein interaction sites using PSIVER and successfully designed a peptide for preventing protein complex formation of a novel estrogen receptor regulator and thereby inhibiting cell growth

CURRENT AND RECENT GRANTS HELD

(see the Japanese page)

TEACHING EXPERIENCE

Department of Applied Mathematics and Theoretical Physics, University of Cambridge

  • Master’s programme in Computational Biology (2004-2006) Coordinator of the module ‘Structural Biology’ (lectures, laboratory sessions and assessment).

Department of Biochemistry, University of Cambridge

  • The Natural Sciences Tripos (undergraduate), Part II (third year) Biochemistry core course lectures: “bioinformatics” (2000-2006).
  • Postgraduate methodology course (Molecular biology and biochemistry in the post-genomic research era): “Bioinformatics modeling and computational biochemistry” (2002-2006).
  • Undergraduate projects (2000-2006)

(Other institutions)
School of Information Systems and School of Biological Sciences, University of East Anglia, Norwich

  • MSc in Bioinformatics (module “Protein, Structure, Prediction and Modelling”). Lecture and practical (March 2003, March 2004, March 2005)

Université Libre de Bruxelles

  • Inter-University Master’s course in Bioinformatics. Lecture and practical (Nov 2003, Jan 2003)

MRC Rosalind Franklin Centre for Genomics Research Protein Structure Prediction course, Cambridge (Dec 2004)

BBSRC Bioinformatics Summer School, Hinxton, Genome Campus

  • Lecture “Fold recognition and comparative modeling” (Oct 2000)
  • Lecture “Fold recognition and comparative modeling” (Oct 2000)

Tokushima University Medical School (2014-)

  • Undergraduate lectures in Biochemistry

Kyoto University, Graduate School of Pharmaceutical Sciences (2015)

(PhD supervision)
Department of Biochemistry, University of Cambridge (2000-2006)
Graduate School of Frontier Biosciences, Osaka University (2007-)

PUBLICATIONS