Bibliography
Works highlighting significance of protein structure CCRs in protein function

Keskin O, Ma B, Nussinov R., Hot regions in protein--protein interactions: the organization and contribution of structurally conserved hot spot residues. J Mol Biol. 2005 Feb 4;345(5):1281-94. Epub 2004 Dec 2.

Keskin O, Ma B, Rogale K, Gunasekaran K, Nussinov R. Protein-protein interactions: organization, cooperativity and mapping in a bottom-up Systems Biology approach. Phys Biol. 2005 Jun;2(2):S24-35.

Li X, Keskin O, Ma B, Nussinov R, Liang J. Protein-protein interactions: hot spots and structurally conserved residues often locate in complemented pockets that pre-organized in the unbound states: implications for docking. J Mol Biol. 2004 Nov 26;344(3):781-95.

Halperin I, Wolfson H, Nussinov R. Protein-protein interactions; coupling of structurally conserved residues and of hot spots across interfaces. Implications for docking. Structure. 2004 Jun;12(6):1027-38.

del Sol A, O'Meara P. Small-world network approach to identify key residues in protein-protein interaction. Proteins. 2005 Feb 15;58(3):672-82.

Haliloglu T, Keskin O, Ma B, Nussinov R. How similar are protein folding and protein binding nuclei? Examination of vibrational motions of energy hot spots and conserved residues. Biophys J. 2005 Mar;88(3):1552-9. Epub 2004 Dec 13.

Ma B, Elkayam T, Wolfson H, Nussinov R. Protein-protein interactions: structurally conserved residues distinguish between binding sites and exposed protein surfaces. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5772-7. Epub 2003 May 1.

Yogurtcu ON, Erdemli SB, Nussinov R, Turkay M, Keskin O. Restricted mobility of conserved residues in protein-protein interfaces in molecular simulations. Biophys J. 2008 May 1;94(9):3475-85. Epub 2008 Jan 28.

Hu Z, Ma B, Wolfson H, Nussinov R. Conservation of polar residues as hot spots at protein interfaces. Proteins. 2000 Jun 1;39(4):331-42.

Sinha N, Smith-Gill SJ. Electrostatics in protein binding and function. Curr Protein Pept Sci. 2002 Dec;3(6):601-14. Review.

Shulman-Peleg A, Shatsky M, Nussinov R, Wolfson HJ. Spatial chemical conservation of hot spot interactions in protein-protein complexes. BMC Biol. 2007 Oct 9;5:43.

Ahmad S, Keskin O, Sarai A, Nussinov R. Protein-DNA interactions: structural, thermodynamic and clustering patterns of conserved residues in DNA-binding proteins. Nucleic Acids Res. 2008 Oct;36(18):5922-32. Epub 2008 Sep 18.

Brinda KV, Vishveshwara S. Oligomeric protein structure networks: insights into protein-protein interactions. BMC Bioinformatics. 2005 Dec 10;6:296.

Bogan AA, Thorn KS. Anatomy of hot spots in protein interfaces. J Mol Biol. 1998 Jul 3;280(1):1-9. Review.

Gao Y, Wang R, Lai L. Structure-based method for analyzing protein-protein interfaces. J Mol Model. 2004 Feb;10(1):44-54. Epub 2003 Nov 22.

Guney E, Tuncbag N, Keskin O, Gursoy A. HotSprint: database of computational hot spots in protein interfaces. Nucleic Acids Res. 2008 Jan;36(Database issue):D662-6. Epub 2007 Oct 24.

Grosdidier S, Fernández-Recio J. Identification of hot-spot residues in protein-protein interactions by computational docking. BMC Bioinformatics. 2008 Oct 21;9:447.

Desrosiers DC, Peng ZY. A binding free energy hot spot in the ankyrin repeat protein GABPbeta mediated protein-protein interaction. J Mol Biol. 2005 Nov 25;354(2):375-84. Epub 2005 Oct 3.

Kortemme T, Baker D. A simple physical model for binding energy hot spots in protein-protein complexes. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14116-21. Epub 2002 Oct 15.

Robertson AD. Intramolecular interactions at protein surfaces and their impact on protein function. Trends Biochem Sci. 2002 Oct;27(10):521-6. Review.

Chung JL, Wang W, Bourne PE. Exploiting sequence and structure homologs to identify protein-protein binding sites. Proteins. 2006 Mar 15;62(3):630-40.

Wong SE, Baron R, McCammon JA. Hot-spot residues at the E9/Im9 interface help binding via different mechanisms. Biopolymers. 2008 Nov;89(11):916-20.

Shaul Y, Schreiber G. Exploring the charge space of protein-protein association: a proteomic study. Proteins. 2005 Aug 15;60(3):341-52.

DeLano WL. Unraveling hot spots in binding interfaces: progress and challenges. Curr Opin Struct Biol. 2002 Feb;12(1):14-20. Review.