Following ROC data was obtained during training of 159 proteins for predicting single nucleotide and nucleotide steps using neural network. (SDCPred returns real values and binding information is obtained at various cutoffs as in the following tables)


Overall single nucleotide-wise average ROC
AUC of ROC (Ade) 76.9%
AUC of ROC (Cyt) 76.5%
AUC of ROC (Gua) 77.4%
AUC of ROC (Thy) 76.0%

Detailed ROC Data:

Cutoff Sensitivity (Ade) Specificity (Ade) Sensitivity (Cyt) Specificity (Cyt) Sensitivity (Gua) Specificity (Gua) Sensitivity (Thy) Specificity (Thy)
0 1 0 1 0 1 0 1 0
0.1 0.97 0.26 0.98 0.17 0.93 0.35 0.98 0.09
0.2 0.90 0.45 0.93 0.37 0.85 0.54 0.94 0.27
0.3 0.82 0.57 0.85 0.53 0.78 0.64 0.88 0.45
0.4 0.75 0.64 0.77 0.65 0.70 0.71 0.80 0.59
0.5 0.69 0.71 0.64 0.73 0.62 0.77 0.69 0.70
0.6 0.61 0.77 0.52 0.81 0.54 0.83 0.59 0.78
0.7 0.52 0.83 0.38 0.88 0.45 0.88 0.46 0.86
0.8 0.40 0.89 0.23 0.94 0.32 0.92 0.23 0.93
0.9 0.20 0.95 0.05 0.98 0.16 0.97 0.03 0.99

AUC of ROC for binding to Dinucleotide steps
AUC of ROC (AA/TT) 77.6%
AUC of ROC (AC/GT) 77.3%
AUC of ROC (AG/CT) 74.7%
AUC of ROC (AT/AT) 75.3%
AUC of ROC (CA/TG) 78.6%
AUC of ROC (CC/GG) 75.9%
AUC of ROC (CG/CG) 73.4%
AUC of ROC (GA/TC) 75.6%
AUC of ROC (GC/GC) 74.3%
AUC of ROC (TA/TA) 78.8%

Detailed ROC Data
Cutoff Sensitivity (AA/TT) Specificity (AA/TT) Sensitivity (AC/GT) Specificity (AC/GT) Sensitivity (AG/CT) Specificity (AG/CT) Sensitivity (AT/AT) Specificity (AT/AT) Sensitivity (CA/TG) Specificity (CA/TG) Sensitivity (CC/GG) Specificity (CC/GG) Sensitivity (CG/CG) Specificity (CG/CG) Sensitivity (GA/TC) Specificity (GA/TC) Sensitivity (GC/GC) Specificity (GC/GC) Sensitivity (TA/TA) Specificity (TA/TA)
0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
0.1 0.98 0.10 0.98 0.14 0.96 0.21 0.96 0.26 0.98 0.21 0.97 0.17 0.95 0.19 0.96 0.22 0.98 0.22 1 0.00
0.2 0.95 0.26 0.94 0.37 0.90 0.37 0.90 0.44 0.93 0.37 0.94 0.34 0.92 0.35 0.92 0.37 0.93 0.37 0.98 0.12
0.3 0.90 0.40 0.85 0.53 0.86 0.49 0.83 0.56 0.89 0.48 0.89 0.47 0.87 0.46 0.86 0.48 0.89 0.47 0.94 0.30
0.4 0.86 0.52 0.76 0.65 0.80 0.58 0.73 0.65 0.83 0.59 0.82 0.58 0.81 0.56 0.81 0.57 0.81 0.56 0.90 0.47
0.5 0.80 0.62 0.65 0.75 0.72 0.66 0.65 0.73 0.76 0.68 0.72 0.67 0.71 0.65 0.73 0.65 0.75 0.64 0.84 0.62
0.6 0.70 0.72 0.48 0.85 0.63 0.73 0.51 0.80 0.65 0.77 0.60 0.76 0.61 0.73 0.65 0.73 0.64 0.72 0.71 0.75
0.7 0.56 0.81 0.27 0.93 0.53 0.80 0.36 0.87 0.49 0.85 0.46 0.84 0.44 0.81 0.54 0.81 0.47 0.79 0.41 0.87
0.8 0.38 0.90 0.10 0.97 0.38 0.88 0.22 0.92 0.31 0.93 0.24 0.92 0.30 0.89 0.38 0.89 0.32 0.87 0.17 0.96
0.9 0.14 0.97 0.01 0.99 0.17 0.94 0.08 0.97 0.04 0.99 0.03 0.99 0.11 0.97 0.14 0.96 0.15 0.95 0.01 0.99