Research Topics

Research Scientist, Mari Itoh, Postdoctoral Fellow, Hitoshi Kawashima, Postdoctoral Fellow, Reiko Watanabe, Project Researcher, Takeshi Fujiwara and Tsuyoshi Esaki will give poster presentation at Chem-Bio Informatics Society(CBI).

2019-10-22 ~ 2019-10-24

Tower Hall Funabori

(4 Chome-1-1 Funabori, Edogawa City, Tokyo 134-0091)

Research Scientist, Mari Itoh, Postdoctoral Fellow, Hitoshi Kawashima, Postdoctoral Fellow, Reiko Watanabe, Project Researcher, Takeshi Fujiwara and Tsuyoshi Esaki will give poster presentation at Chem-Bio Informatics Society(CBI).

  • P5-06 (Development of a pharmacokinetics prediction system using multiscale integrated modeling: 13. Development of DruMAP, Drug Metabolism and pharmacokinetics Analysis Platform)
  • P5-07 (Development of a pharmacokinetics prediction system using multiscale integrated modeling: 14. In silico three-class predictor of human intestinal absorption with Caco-2 permeability and dried-DMSO solubility)
  • P5-08 (Development of a pharmacokinetics prediction system using multiscale integrated modeling:15. Development of an in silico prediction system of human renal excretion and clearance from chemical structure information)
  • P6-09 (Computational drug target prediction using PU learning approach)

More information is available at the following links.

2019-10-23

Postdoctoral Fellow, Hitoshi Kawashima and Postdoctoral Fellow, Reiko Watanabe will give poster presentation at American Association of Pharmaceutical Scientists (AAPS).

2019-11-03 ~ 2019-11-06

Henry B. Gonzalez Convention Center

(900 E Market St, San Antonio, TX 78205, United States)

Postdoctoral Fellow, Hitoshi Kawashima and Postdoctoral Fellow, Reiko Watanabe will give poster presentation at American Association of Pharmaceutical Scientists (AAPS).

  • Development of DruMAP, Drug Metabolism and pharmacokinetics Analysis Platform
  • Development of in silico prediction models to evaluate pharmacokinetic profiles using chemical structure information

More information is available at the following links.

2019-10-23

Project Leader, Kenji Mizuguchi will give an invited lecture at The 4th Symposium of the Inter-University Research Network for Trans-Omics Medicine.

2019-11-14 13:00 ~ 2019-11-15 16:00

Institute for Genome Research, Tokushima University

(3-18-15 Kuramotochō, Tokushima, 770-0042)

Project Leader, Kenji Mizuguchi will give an invited lecture at The 4th Symposium of the Inter-University Research Network for Trans-Omics Medicine.

  • Artificial intelligence-based drug discovery: challenges and applications to target identification and pharmacokinetic modelling

More information is available at the following links.

2019-10-09

Postdoctoral Fellow, Jonguk Park will give oral presentation at The 61st Annual Meeting of Japanese Association for Oral Biology.

2019-10-12

Tokyo Dental College

(2 Chome-9-18 Misakicho, Chiyoda City, Tokyo 101-0061)

Postdoctoral Fellow, Jonguk Park will give oral presentation at The 61st Annual Meeting of Japanese Association for Oral Biology.

  • Analysis of oral microbiota in Japanese oral cancer patients using 16S rRNA sequencing

More information is available at the following links.

2019-10-02

Project Leader, Kenji Mizuguchi will give a speech at The 14th International Symposium of the Institute Network for Biomedical Sciences.

2019-10-02

Alumnus Union Building of Osaka University Medical School

(2-2 Yamadaoka, Suita, Osaka 565-0871)

Project Leader, Kenji Mizuguchi will give a speech at The 14th International Symposium of the Institute Network for Biomedical Sciences.

  • Data integration as a basis for artificial intelligence in drug discovery

More information is available at the following links.

2019-09-12
› more

General News

Dr. Reiko Watanabe won the Excellent poster award@CBI2019.(2019.10.24)

IMG_5049 IMG_5047 (002)

Poster Title: ”Development of a pharmacokinetics prediction system using multiscale integrated modeling:15. Development of an in silico prediction system of human renal excretion and clearance from chemical structure information”

Author: Reiko Watanabe, Rikiya Ohashi, Tsuyoshi Esaki, Hitoshi Kawashima,
Yayoi Natsume-Kitatani, Chioko Nagao, Kenji Mizuguchi

please see more details here

We welcomed Mr. Rajnish Kumar as part of JSPS (Japan Society for the Promotion of Science) Summer Program.

Date 2019-07-11 ~ 2019-08-05

placeNational Institutes of Biomedical Innovation, Health and Nutrition. Bioinformatics project.

 We welcomed Mr. Rajnish Kumar as part of JSPS (Japan Society for the Promotion of Science) Summer Program.Mr. Rajnish Kumar is Assistant Professor at Karolinska Institutet (Alzheimer’s disease drug discovery research at Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics).

For the past 3 weeks, we had substantial communication.

Prior to the end of program, we had a luncheon party as farewell party.

comp_DSCN9405

2019-08-09

Postdoctoral Research Associate in Bioinformatics(2018.12.21)

[Overview]
In the Bioinformatics and Computational Biology Group at the NIBIOHN, we carry out bioinformatics and computational biology research into drug discovery and development (with special emphasis on data integration, target discovery and safety assessment). Our research involves both the analysis of real-life experimental data and the development of novel computational techniques, aiming to establish systems approaches to drug discovery.

See mizuguchilab.org for more details.

Two positions of postdoctoral research associate are currently open, working on one of the following projects: 1) the development of a pharmacokinetic modelling platform, 2) drug target discovery with artificial intelligence and 2) drug design to modulate biological macromolecular interactions.

[Qualification requirements]
The successful applicant has or will have a PhD degree in a subject relevant to our research, including computational biology (bioinformatics, systems biology), computer science, statistics, pharmacology, chemistry (computational chemistry, medicinal chemistry) and biology (structural biology, molecular and cell biology). At least one of the following conditions must be satisfied: 1) a strong background in software engineering and the ability to develop novel biofinformatic software/databases with new technologies including big data analytics and artificial intelligence, 2) experience in handling clinical and/or large-scale biological data such as those from transcriptomic and proteomic experiments and 3) the ability to analyze small-molecule compounds and their targets using tools in chemoinformatics and computer-aided drug design.

A good balance of scientific and interpersonal skills will be essential and willingness to tackle interdisciplinary research questions is advantageous.

[Location]
National Institutes of Biomedical Innovation, Health and Nutrition
7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan.

[Contract Conditions]
The position is full time and until the end of March 2020 in the first instance, renewable annually upon evaluation (subject to funding availability). Terms and conditions of appointment will apply, including salary and health insurance, in accordance with NIBIOHN’s standard procedures for appointing postdoctoral research associates.

[Start of Employment]
1 April 2019, or as appropriate based on the needs of the successful candidate.

[Application]
Applications, including a full curriculum vitae, a list of publications, a short statement of previous research and future plans and contact details of two referees, should be e-mailed to the address below.

[Deadline]
31 January 2019 (may be closed early, if the position is filled).

[Selection Process]
Shortlisted candidates will be notified and invited for interview (in person or by phone).

Informal enquiries may be directed to Dr Kenji Mizuguchi (kenji@nibiohn.go.jp, +81-72-641-9890). See http://mizuguchilab.org for further information.

Contact
Dr Kenji Mizuguchi kenji@nibiohn.go.jp
National Institutes of Biomedical Innovation, Health and Nutrition
7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan
Tel: +81 72 641 9890
Fax: +81 72 641 9881

› more