National Institutes of Biomedical Innovation, Health and Nutrition
Institute for Protein Research
Kenji
Kenji Mizuguchi Ph.D.
  • Director, Artificial Intelligence Center for Health and Biomedical Research (ArCHER), NIBIOHN
  • Professor of Computational Biology, Institute for Protein Research, Osaka University
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BRIEF PERSONAL HISTORY

  • 1990

    BA in Physics (unclassified), Faculty of Science, Kyoto University
  • 1992

    MSc in Chemistry (unclassified), Department of Chemistry, Kyoto University
  • 1995

    PhD in Chemistry (unclassified), Department of Chemistry, Kyoto University
  • 1995

    Visiting Scholar (Fellow of the Japan Society for the Promotion of Science)

    Department of Crystallography, Birkbeck College, University of London

  • 1996

    Long-Term Fellow of the Human Frontier Science Program

    Department of Biochemistry, University of Cambridge

  • 1998

    Research Associate

    Department of Biochemistry, University of Cambridge

  • 2000

    The Wellcome Trust Research Career Development Fellow (hosting an independent research laboratory)

    Department of Biochemistry, University of Cambridge

  • 2004

    University Lecturer

    Department of Applied Mathematics and Theoretical Physics (jointly held in Department of Biochemistry), University of Cambridge

  • 2006 - Present

    Group Leader

    National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)

  • 2007 - Present

    Guest Professor

    Graduate School of Frontier Biosciences, Osaka University

  • 2015 - Present

    Guest Professor

    Graduate School of Pharmaceutical Sciences, Osaka University

  • 2019 - Present

    Director

    Artificial Intelligence Center for Health and Biomedical Research (ArCHER), NIBIOHN

  • 2019 - Present

    Professor

    Institute for Protein Research, Osaka University

RESEARCH INTERESTS

Bioinformatics and computational biology for drug discovery

Major achievements

Development of a highly successful method for protein structure prediction

  • FUGUE
  • One of the best performing structure prediction methods at the CASP (Critical Assessment of Techniques for Protein Structure Prediction) and other international experiments
  • Among the most popular software programmes of its kind (cited >1000; JMB 2001)
  • Commercialized by Tripos Inc.

Data integration and database development

  • TargetMine , an integrated data warehouse for candidate gene prioritization and target discovery
  • Toxyagtes , interactive toxicity analysis on a hybrid microarray and linked data platform
  • HOMSTRAD , one of the first on-line databases for structure-based alignments

Successful (experimentally validated) predictions of protein structure, function and interaction

  • Examples include developmental regulators, metabolic enzymes in pathogenic microorganisms and proteins involved in cancer and psychiatric disorders
  • Identified potential novel targets for hepatitis C and other diseases using TargetMine
  • Predicted protein interaction sites using PSIVER and successfully designed a peptide for preventing protein complex formation of a novel estrogen receptor regulator and thereby inhibiting cell growth

CURRENT AND RECENT GRANTS HELD

TEACHING EXPERIENCE

Department of Applied Mathematics and Theoretical Physics, University of Cambridge

  • Master’s programme in Computational Biology (2004-2006) Coordinator of the module ‘Structural Biology’ (lectures, laboratory sessions and assessment).

Department of Biochemistry, University of Cambridge

  • The Natural Sciences Tripos (undergraduate), Part II (third year) Biochemistry core course lectures: “bioinformatics” (2000-2006).
  • Postgraduate methodology course (Molecular biology and biochemistry in the post-genomic research era): “Bioinformatics modeling and computational biochemistry” (2002-2006).
  • Undergraduate projects (2000-2006)

(Other institutions)

  • School of Information Systems and School of Biological Sciences, University of East Anglia, Norwich
    • MSc in Bioinformatics (module “Protein, Structure, Prediction and Modelling”). Lecture and practical (March 2003, March 2004, March 2005)
  • Université Libre de Bruxelles
    • Inter-University Master’s course in Bioinformatics. Lecture and practical (Nov 2003, Jan 2003)
  • MRC Rosalind Franklin Centre for Genomics Research Protein Structure Prediction course, Cambridge (Dec 2004)
  • BBSRC Bioinformatics Summer School, Hinxton, Genome Campus
    • Lecture “Fold recognition and comparative modeling” (Oct 2000)
    • Lecture “Fold recognition and comparative modeling” (Oct 2000)

Tokushima University Medical School (2014-)

  • Undergraduate lectures in Biochemistry

Kyoto University, Graduate School of Pharmaceutical Sciences (2015)

(PhD supervision)

  • Department of Biochemistry, University of Cambridge (2000-2006)
  • Graduate School of Frontier Biosciences, Osaka University (2007-)

PUBLICATIONS

Original articles(researchmap)

Reviews and commentaries(researchmap)

Book chapters(researchmap)

Citation metrics(Google Scholar)

Postprints(OUKA)

VIDEOS