National Institutes of Biomedical Innovation, Health and Nutrition
Institute for Protein Research

Prediction of protein-protein interactions

1. Predicting whether two proteins interact or not given their amino acid sequences

PSOPIA-e.jpg

  • Go to the PSOPIA site. PSOPIA

Reference

  1. Murakami, Y. and Mizuguchi, K. (2014). “Homology-based prediction of interactions between proteins using Averaged One-Dependence Estimators”, BMC Bioinformatics, 15:213.
2. Predicting protein-binding sites given a single amino acid sequence

PSIVER-e.jpg

  • Go to the PSIVER site. PSIVER

Reference

  1. Murakami, Y. and Mizuguchi, K. (2010). “Applying the Naive Bayes classifier with kernel density estimation to the prediction of protein-protein interaciton sites”, Bioinformatics, 26 (15): 1841-1848. doi:10.1093/bioinformatics/btq302
3. Predicting protein-binding sites given a pair of amino acid sequences
  • Go to the PPiPP site. PPiPP

Reference

  1. Ahmad, S. and Mizuguchi, K. (2011). “Partner-aware prediction of interacting residues in protein-protein complexes from sequence data”, PLoS One (2011) 6(12)e29104.
  2. 水口賢司、(2015)、タンパク質間相互作用「生命ネットワークの基本部品の構造を解明する」、日本生物物理学会